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Keyed in multiple places:

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Key to Cephalanthus

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1 Outer surface of the calyx glabrous (or the tube with a few long white hairs near the base); [widespread in our region]
1 Outer surface of the calyx densely pubescent with short, appressed hairs; [extreme s. TX only]

Key to Rubiaceae

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1 Trees, shrubs, or woody vines.
..2 Prostrate or climbing woody vine (liana), rooting at nodes; corolla lilac; [alien]; [subfamily Rubioideae; tribe Paederieae]
..2 Shrub or tree (sometimes somewhat scrambling, but not rooting at nodes); corolla white, green, maroon, or orange-red; [native or alien].
....3 Inflorescence spherical or globular; [collectively widespread]
......4 Fruits dry, dehiscent; [subfamily Cinchonoideae; tribe Naucleeae]
......4 Fruits fleshy, indehiscent; [subfamily Rubioideae; tribe Morindeae]
....3 Inflorescence cymose, thyrsoid, or corymbose; [Coastal Plain, from s. SC southward].
........5 Flowers orange-red; leaves usually whorled; [subfamily Cinchonoideae; tribe Hamelieae]
........5 Flowers white, green, or maroon; leaves opposite.
..........6 Flowers solitary, terminal; [subfamily Ixoroideae; tribe Gardenieae]
..........6 Flowers in cymose or thyrsoid inflorescences.
............ 7 Inflorescence cymose; some calyx lobes expanded into pink or reddish “flags”; leaves deciduous; domatia not present; [of s. SC southward]; [subfamily Ixoroideae; tribe Condamineeae]
............ 7 Inflorescences thyrsoid; calyx lobes inconspicuous; leaves evergreen; domatia present in secondary vein axils; [of ne. FL southward]
............ ..8 Lateral veins 3-6 on either side of the midvein; fruit white; petals yellowish, > 6 mm long; [subfamily Cinchonoideae; tribe Chiococceae]
............ ..8 Lateral veins 8-14 on either side of the midvein; fruit red; petals white, <5 mm long; [subfamily Rubioideae; tribe Psychotrieae]
1 Herbs (or creeping subshrubs in Mitchella).
............ ....9 Leaves whorled; [subfamily Rubioideae; tribe Rubieae]
............ ....9 Leaves opposite
............ ......10 Flowers paired, the ovaries connate and developing into a single fleshy red fruit; leaves roundish; creeping subshrub; [subfamily Rubioideae; tribe Mitchelleae]
............ ......10 Flowers single or in inflorescences with multiple flowers, the fruits either dry or fleshy and yellowish or black; leaves various; herb; [subfamily Rubioideae; tribe Spermacoceae].
............ ........11 Carpels with few to many seeds.
............ ..........12 Corolla 4-lobed.
............ ............ 13 Capsule longer than the calyx tube; flowers blue, pink, or white
............ ............ 13 Capsule not longer than the calyx tube; flowers white
............ ........11 Carpels 1-seeded.
............ ............ ..14 Flowers in dense, terminal, involucrate heads; flowers 4- or-6-lobed; styles 3
............ ............ ..14 Flowers in axillary or terminal clusters, or single in axils, not involucrate; flowers 4-lobed; styles 2.
............ ............ ....15 Flowers usually solitary in leaf axils; fruit separating into 2 parts.
............ ............ ......16 Sepals 4 and similar in size; style entire; [of dry habitats]
............ ............ ......16 Sepals 2 (or 4, and then markedly dimorphic); style cleft; [of moist to wet habitats]
............ ............ ....15 Flowers in terminal and axillary clusters; fruits not separating into 2 parts.
............ ............ ........17 Carpels opening longitudinally

Key H: woody plants with whorled leaves

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1 Leaves tiny, bract-like, triangular, 6-14 (-17) per node
1 Leaves either needle-like, scale-like, or flattened and large, (2-) 3-4 (-6) per node.
..2 Leaves needle-like or scale-like, terete, angled, or flat in ×-section, < 2 cm long; leaves (2-) 3-4 (-6) per node
..2 Leaves flat, > 3 cm long; leaves (2-) 3 per node; [Eudicots].
....3 Plant a subshrub, < 3 dm tall, with < 10 leaves per stem.
......4 Leaves entire, broadly elliptic; flowers numerous, in a hemispherical head, subtended by 4 large white bracts
......4 Leaves serrate, narrowly ovate or narrowly obovate; flowers (1-) 2-8 in a long-peduncled umbel or corymb, not subtended by bracts
....3 Plant a shrub or tree, > 3 dm tall, with many > 10 leaves per stem.
........5 Leaves toothed, and most leaves also lobed
........5 Leaves entire, not lobed.
..........6 Leaves cordate at base; leaves about as long as wide; medium to large tree.
............ 7 Flowers white to yellow; capsules linear, >10× as long as wide; leaf undersurface with curly simple hairs; nectar glands present in the main vein axils on the undersurface of the leaf (visible from the underside or the upperside in fresh leaves and herbarium specimens as a triangle 1-4 mm on a side)
............ 7 Flowers lavender; capsules ellipsoid, < 2× as long as wide; leaf undersurface with branched (dendritic or stellate) hairs; nectar glands absent
..........6 Leaves cuneate to rounded at base; leaves > 1.5× as long as wide; shrub to small tree.
............ ..8 Leaves rounded at the tip
............ ..8 Leaves acute to acuminate at the tip.
............ ....9 Leaves lanceolate (> 2.5× as long as wide), the secondary venation not prominent; inflorescences axillary or terminal; flowers pink or white.
............ ......10 Inflorescences terminal; flowers pink or white; leaves thick and leathery; [alien plants of uplands, persistent or weakly naturalized]
............ ......10 Inflorescences axillary; flowers pink; leaves thin and herbaceous; [native plants of wetlands]
............ ....9 Leaves ovate (< 2× as long as wide), the secondary venation prominent and arching-parallel; inflorescences terminal; flowers white, greenish-yellow, red, or orange.
............ ........11 Flowers in a spherical or hemispherical head; corollas white or greenish-yellow
............ ........11 Flowers in a monochasial helicoid cyme; corollas red to orange